Homology-independent targeted integration in vivo restores Cldn11 deficiency in mouse Sertoli cells and spermatogenesis
T Zhang, Anhao Guo, Hanben Wang, Yuan Chen, Lufan Li, Xin Wu
This study uses HITI gene editing in mouse Sertoli cells to restore Cldn11 function and rescue spermatogenesis and fertility in Cldn11-deficient mice.
bioRxiv · Dec 25, 2025 · PreprintGenomics