New Insights into the Conformational Activation of Full-Length Integrin
Tamara C. Bidone, Anirban Polley, Aleksander Durumeric, Tristan Driscoll, Daniel Iwamoto, David Calderwood, Martin A. Schwartz, Gregory A Voth
This study investigates integrin conformational activation pathways using simulations and experiments, supporting a 'deadbolt' model over a 'switchblade-like' mechanism.
bioRxiv · Oct 15, 2017 · PreprintBiophysics