Off-target effects of Cre recombinase reveal limits of adoptive T cell transfers and persistent proliferation of effector CD8 T-cells
Lisa Borkner, Anja Drabig, Xiaoyan Zheng, Julia Drylewicz, Thomas Marandu, Mariona Baliu-Piqué, Suzanne van Duikeren, Ramon Arens, Kiki Tesselaar, José AM Borghans, Luka Čičin-Šain
The paper shows that effector memory T-cells (TEM) proliferate during persistent CMV infection, maintaining memory inflation, while central memory T-cells (TCM) do not proliferate as much.
bioRxiv · Dec 20, 2018 · PreprintImmunology