Structural survey of HIF-2α reveals regulation of its subcellular localization and protein interactome
Tomáš Gregor, Sinan Karakaya, Anja Zethraeus, Stina Ostenberg, Elina Fredlund, Emma U. Hammarlund, Jenny Hansson, Jared Rosenblum, Sofie Mohlin
This study investigates HIF-2α's structural features and reveals its non-canonical cytoplasmic localization and protein interactions, challenging previous assumptions about its function and tumor-promoting role.
bioRxiv · May 7, 2026 · PreprintCell Biology