Greater hypoxic burden predicts weaker coordination between brain pulsation and CSF flow on 7T MRI independent of non-hypoxic arousals: Implications for glymphatic activity
Gawon Cho, Korey Kam, Anne Chen, Yutong Mao, Helene Benveniste, Adam P. Mecca, Daphne I. Valencia, Katarina Martillo, Sarah Shan Hang Chu, Ankita Kumar, Omonigho M. Bubu, Ricardo S. Osorio, Indu A. Ayappa, X M Liu, Brienne Miner, Andrew W. Varga
This study finds that greater hypoxic burden in OSA is linked to weaker coordination between brain pulsation and CSF flow, suggesting impaired glymphatic activity.
bioRxiv · May 23, 2026 · PreprintNeuroscience