Aggregation-prone peptides modulate interferon gamma functionality in naturally occurring protein nanoparticles
José Vicente Carratalá, Olivia Cano-Garrido, Julieta Sánchez, Cristina Membrado, Eudald Pérez, Oscar Conchillo-Solé, Xavier Daura, Alejandro Sánchez-Chardi, Antonio Villaverde, Anna Arís, Elena Garcia-Fruitós, Neus Ferrer-Miralles
This study shows that aggregation-prone peptides enhance the formation of protein nanoparticles from interferon-gamma in Lactococcus lactis, with compact protein conformations correlating with increased biological activity.
bioRxiv · Jan 3, 2019 · PreprintMicrobiology