Aβ Aggregates Bind the U1 Spliceosomal Ribonucleoprotein in Alzheimer Disease Brain
Youqi Tao, Anna E. Francis, Wen Liu, Christopher Watkins, David Alan Bennett, Dennis J. Selkoe, Ryan A. Flynn, Andrew M. Stern
The paper identifies that Aβ aggregates bind the U1 snRNP in Alzheimer's disease brain, linking Aβ aggregation to spliceosome dysfunction and connecting it to other fibril-forming proteins in neurodegenerative diseases.
bioRxiv · Jun 5, 2026 · PreprintNeuroscience