G-quadruplex formation in GCK and TM6SF2 are targets for differential DNA methylation in metabolic disease and hepatocellular carcinoma patients
Angelika Lahnsteiner, Victoria Ellmer, Anna Oberlercher, Zita Liutkevičiūtė, Esther Schönauer, Bernhard Paulweber, Elmar Stephan Aigner, Angela Risch
The paper investigates DNA methylation changes in GCK and TM6SF2 regions associated with metabolic diseases and hepatocellular carcinoma, revealing their impact on G-quadruplex formation and gene regulation.
bioRxiv · Mar 21, 2024 · PreprintGenetics