Unconventional structure and function of PHD domains from Additional Sex Combs-like proteins
Cameron J. Reddington, Annabel R. Walsh, Torsten Kleffmann, Christoph Göbl, Peter D. Mace
This paper shows that the ASXL PHD domain lacks histone tail recognition features and binds Zinc ions differently, forming complexes with MBD5 and MBD6 that have a composite Zinc-binding site.
FEBS Journal · Jul 29, 2025Peer-reviewedBiochemistry