Balancing selection at a premature stop mutation in the myostatin gene underlies a recessive leg weakness syndrome in pigs
Oswald Matika, Diego Robledo, Ricardo Pong‐Wong, Stephen Christopher Bishop, Valentina Riggio, Heather A. Finlayson, Natalie R Lowe, Annabelle E. Hoste, Grant A. Walling, Jorge del Pozo, Alan L. Archibald, John Arthur Woolliams, Ross D. Houston
The paper identifies a recessive leg weakness syndrome in pigs caused by a premature stop mutation in the MSTN gene, showing balancing selection due to heterozygous advantage.
PLoS Genetics · Jan 30, 2019Peer-reviewedGenetics