BiophysicsbioRxivPreprint
Systematic mapping of the free energy landscapes of a growing immunoglobulin domain identifies a kinetic intermediate associated with co-translational proline isomerization
Christopher A. Waudby, Maria-Evangelia Karyadi, Tomasz Wlodarski…·John Christodoulou
The paper maps free energy landscapes of an immunoglobulin domain during translation, identifies a kinetic intermediate linked to proline isomerization, and shows the necessity of peptidyl-prolyl isomerases to prevent misfolding.
DOI 10.1101/189050