Systematic mapping of the free energy landscapes of a growing immunoglobulin domain identifies a kinetic intermediate associated with co-translational proline isomerization
Christopher A. Waudby, Maria-Evangelia Karyadi, Tomasz Wlodarski, Anaïs M. E. Cassaignau, Sammy Chan, Julian M. Schmidt-Engler, Anne S. Wentink, Carlo Camilloni, Michele Vendruscolo, Lisa D. Cabrita, John Christodoulou
The paper maps free energy landscapes of an immunoglobulin domain during translation, identifies a kinetic intermediate linked to proline isomerization, and shows the necessity of peptidyl-prolyl isomerases to prevent misfolding.
bioRxiv · Sep 14, 2017 · PreprintBiophysics