Generative design of antibody Fc-variants with synthetic and programmable functional profiles
Edward B. Irvine, Thomas Bikias, Evangelos Stamkopoulos, Lester Frei, Nick Schürmann, Annmaree K. Warrender, Helen Schmid, Dimitri Coukos, Huilin Yang, Mason Minot, William Kelton, Sai T. Reddy
This study designs antibody Fc-variants with programmable functional profiles using deep learning and experimental validation.
bioRxiv · Oct 10, 2025 · PreprintBioengineering