Author

William Kelton

University of WaikatoORCID 0000-0002-5513-6429Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:long-read sequencing· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Edward B. IrvineiD· 2 shared Kevin Beijerling· 2 shared Kyrin R. HanningiD· 2 shared Lester FreiiD· 2 shared Sai T. ReddyiD· 2 shared Alexander YermanosiD· 1 shared Annmaree K. Warrender· 1 shared Beichen GaoiD· 1 shared

Activity by Year

2021-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

Edward B. IrvineORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Generative design of antibody Fc-variants with synthetic and programmable functional profiles

Edward B. Irvine, Thomas Bikias, Evangelos Stamkopoulos, Lester Frei, Nick Schürmann, Annmaree K. Warrender, Helen Schmid, Dimitri Coukos, Huilin Yang, Mason Minot, William Kelton, Sai T. Reddy

This study designs antibody Fc-variants with programmable functional profiles using deep learning and experimental validation.

bioRxiv · Oct 10, 2025 · PreprintBioengineering

Simple high-throughput encoding of deep mutational scanning libraries by oligo-based Golden Gate assembly

Kyrin R. Hanning, Emma J. Walker, Kevin Beijerling, Edward B. Irvine, James Jordan Steel, William Kelton

This paper introduces a method for high-throughput mutational library assembly using oligo-based Golden Gate assembly and validates it by improving nanobody affinity.

bioRxiv · Jul 16, 2025 · PreprintSynthetic Biology

A rapid approach for linear epitope vaccine profiling reveals unexpected epitope tag immunogenicity

Kirsten Browne-Cole, Kyrin R. Hanning, Kevin Beijerling, Meghan Rousseau, Jacelyn M. S. Loh, William Kelton

The paper presents a method using phage-displayed oligo pools and Nanopore sequencing to profile linear epitopes in a vaccine, revealing unexpected immunogenicity of epitope tags.

Scientific Reports · Mar 19, 2025Peer-reviewedImmunology

Predictive profiling of SARS-CoV-2 variants by deep mutational learning

Joseph M. Taft, Cédric R. Weber, Beichen Gao, Roy A. Ehling, Jiami Han, Lester Frei, Sean W. Metcalfe, Alexander Yermanos, William Kelton, Sai T. Reddy

This paper develops deep mutational learning to predict the impact of SARS-CoV-2 spike protein mutations on ACE2 binding and antibody escape, identifying potential variants and supporting vaccine and therapeutic development.

bioRxiv · Dec 7, 2021 · PreprintSynthetic Biology