Maturation-dependent complement production and C3 processing in human retinal pigment epithelium cells
Juliane Schikora, Antonia Nickel, Jasmin Bergert, Rike Hähnel, Aaron Dort, Stella Y. Schayan-Araghi, Pratiti Banerjee, Hannah Nora Wolf, Helen May‐Simera, Diana Pauly
This study compares immature and mature iPSC-RPE and ARPE-19 cells, showing that mature cells secrete active complement forms and process C3 differently, impacting local complement activation.
bioRxiv · Feb 5, 2025 · PreprintCell Biology