Protease suppression by native I9 inhibitor improves recombinant protein production in Trichoderma reesei
Mari J Valkonen, Mykhailo Girych, Sami Havukainen, Emmi Sveholm, Jens C. Luoto, Georg Schmidt, Norman Adlung, Antti Aalto, O. H. Samuli Ollila, Hans Mattila, Tanja Paasela
The paper identifies a native inhibitor, TrI9, from Trichoderma reesei that suppresses protease activity, improving recombinant protein production by reducing proteolysis without compromising strain fitness.
Bioresource Technology · Jul 14, 2026Peer-reviewedBioengineering