Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease
Santiago E. Sanchez, Yuchao Gu, Yan Wang, Anudeep Golla, Annika Martin, William E. Shomali, Dirk F. Hockemeyer, Sharon A. Savage, Steven E. Artandi
This paper uses long-read sequencing to measure telomere length distributions in human cells, finding that aging is associated with loss of long telomeres and accumulation of short ones, and develops a classifier to distinguish healthy aging from telomere disorders.
Nature Communications · Jun 18, 2024Peer-reviewedGenetics