Yan Wang

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

This paper develops a voluntary stretching model in mice and applies it to study its effects on breast tumor growth and plasma protein profiles compared to running.

This paper uses long-read sequencing to measure telomere length distributions in human cells, finding that aging is associated with loss of long telomeres and accumulation of short ones, and develops a classifier to distinguish healthy aging from telomere disorders.

This study identifies a transcriptomic signature and secreted factors from Gs-activated BMSCs in fibrous dysplasia, linking them to pro-inflammatory and pro-osteoclastic behavior and potential therapeutic targets.

The paper integrates metabolomic, proteomic, and phospho-proteomic analyses of dorsal root ganglia from DPN donors and controls to identify molecular changes associated with diabetic neuropathic pain.

The paper evaluates DIA performance across multiple laboratories using standardized samples and provides benchmark datasets for education and tool development.