Multi-stem-loop constrained library enables accelerated SELEX for aptamers with superior kinetics and affinity
Qinuo Wang, Yuhan Zhao, Siyi Zhao, Anyang Wu, Linfeng Hao, Tianduo Hong, Long Hong
This paper develops a multi-stem-loop constrained library to accelerate SELEX for aptamers, resulting in candidates with superior binding kinetics and affinity in fewer rounds.
bioRxiv · Nov 27, 2025 · PreprintBiochemistry