The proteomic landscape and temporal dynamics of mammalian gastruloid development
Riddhiman K. Garge, Valerie Lynch, Rose Fields, Silvia Casadei, Sabrina Best, Jeremy Stone, Matthew W. Snyder, Connor Kubo, Arata Wakimoto, Zukai Liu, Christopher D. McGann, Jay Shendure, Lea M. Starita, Nobuhiko Hamazaki, Devin K. Schweppe
This study uses quantitative proteomics to analyze human and mouse gastruloids at four stages, revealing protein dynamics, discordance with transcriptomes, and gene networks linked to developmental defects.
bioRxiv · Sep 5, 2024 · PreprintSystems Biology