Epigenetic fidelity in complex biological systems and implications for ageing
Thomas Duffield, Laura Csuka, Arda Akalan, Gustavo Daniel Vega Magdaleno, Ludovic Senez, Daniel H. Palmer, João Pedro de Magalhães
This paper identifies epigenetic loci with age-correlated variance, introduces a deep-learning model to predict age from variance, and proposes a theory of systemic ageing through feedback deregulation.
bioRxiv · Apr 29, 2023 · PreprintGenomics