Mesenchymal predominance in olfactory epithelium-derived cultures limits modeling of neurodevelopmental brain disorders
Xoel Mato-Blanco, Silvia Beltramone, Marta Barrera-Conde, Emma Veza-Estévez, Zenaida Piñeiro Agüín, Ares Ramos, Anna Mané, Arnau Cendón, María José Algora, Mayte Gomariz, Claudia Sanchez-Aldabo, Amira Trabsa, Vanessa Sánchez‐Gistau, Pilar Alvarez, Rafael de la Torre, , Gabriel Santpere
This study shows that human olfactory epithelium cultures are mostly mesenchymal cells, not neurogenic, limiting their use for modeling neurodevelopmental disorders.
bioRxiv · Apr 24, 2026 · PreprintNeuroscience