Gerard Muntané

The paper identifies convergent amino-acid substitutions in primate species linked to male-fertility genes and longevity.

This study identifies shared genetic architecture between schizophrenia and substance use disorders using GWAS and genomic methods, finding significant genetic correlations and bidirectional causal relationships.

This study shows that human olfactory epithelium cultures are mostly mesenchymal cells, not neurogenic, limiting their use for modeling neurodevelopmental disorders.

This study meta-analyzes lipoedema cohorts from the UK and Spain with UK Biobank data, identifying overlapping susceptibility loci and rare SNPs associated with the disorder.

Cross-species genome-phenome mapping in primates reveals thousands of protein-coding variants linked to the evolution of complex traits.

The paper introduces a phylogenetic method to detect protein sites associated with continuous traits, showing improved recall but higher computational cost, and applies it to mammalian longevity data.

This study identifies genetic trade-offs between fertility, longevity, and disease risk, showing that disease-risk alleles can persist due to reproductive advantages.

This study presents a multi-omics analysis of a supercentenarian, revealing that extreme age and poor health are distinct molecular processes.

The paper identifies proteins and regulatory elements associated with vocal learning by analyzing bat neural activity and epigenomic data.

CAAStools identifies and validates convergent amino acid substitutions in orthologous protein alignments for predefined species groups.

TOGA integrates gene annotation and orthology inference across hundreds of genomes, improving ortholog detection and creating large comparative gene resources.

A machine learning approach identifies enhancer-phenotype associations across mammals, revealing links to brain size and behavior evolution.

The paper curates TE content in 248 mammalian genomes, finding trends in recent TE accumulation and associations with dietary habits.

The paper uses evolutionary constraint scores to identify functional genomic regions and finds they are enriched for variants associated with common diseases.

The paper identifies bats as a hotspot for horizontal transfer of DNA transposons, finding over 200 putative elements and shared transposons across mammals and reptiles.

This study uses polygenic risk scores to predict BMI increase in first-episode psychosis patients, finding shared genetic variants between schizophrenia and BMI contribute significantly to the prediction.

This paper identifies amino acid changes and genes associated with longevity across mammals, showing their potential to improve human lifespan heritability interpretation.

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.