CSDE1 promotes passenger strand cleavage of miR-486
Arezou Arvand, Yunkoo Ko, Tony Chen, Emily Tsao, Meha K. Patel, Lucas Hiscock, Louis-Mathieu Harvey, Martin J. Simard, Kristin J. Hope, Chanseok Shin, Pavan Kumar Kakumani
The paper identifies CSDE1 as a cofactor that promotes AGO2-dependent passenger-strand cleavage of miR-486-5p, enhancing its maturation and function in hematological malignancies.
RNA Biology · Mar 30, 2026Peer-reviewedMolecular Biology