Integrating multi-covariate disentanglement with counterfactual analysis on synthetic data enables cell type discovery and counterfactual predictions.
Stathis Megas, Arian Amani, Antony Rose, Olli Dufva, Kian Shamsaie, Hesam Asadollahzadeh, Krzysztof Polański, Muzlifah A. Haniffa, Sarah Amalia Teichmann, Mohammad Lotfollahi
CellDISECT improves cell type discovery and counterfactual predictions by disentangling covariates and using synthetic data for training.
bioRxiv · Jun 3, 2025 · PreprintGenomics