The transcription factor BATF pioneers the differentiation program of cytolytic effector CD8+ T cells through the direct interaction with IRF4
Sotaro Fujisawa, Yamato Tanabe, Arisa Hojo, Ryotaro Shiga, Junko Kurachi, Miki Koura, Toshikatsu Tamai, Yusuke Miyanari, E. John Wherry, Makoto Kurachi
This study shows BATF is essential for early chromatin remodeling and effector CD8+ T cell differentiation through its interaction with IRF4.
Cell Reports · Aug 1, 2025Peer-reviewedImmunology