Genome-scale prediction of context-specific synthetic lethality beyond protein interaction networks
Pravin Baskar, Sahoo Parnika, Arnav Lakhdive, Saptarshi Bej, Sanu Shameer, Kamalakannan Vijayan
This paper introduces SLxGO, a network-independent machine learning framework for predicting context-specific synthetic lethal gene pairs, achieving superior performance and validating interactions experimentally.
bioRxiv · Aug 3, 2026 · PreprintSystems Biology