Author

Kamalakannan Vijayan

Indian Institute of Science Education and Research ThiruvananthapuramORCID 0000-0002-0052-7780Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:benchmarking· 2 Approach:machine learning (classical)· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Ling WeiiD· 2 shared Sahoo Parnika· 2 shared Aishani Saha· 1 shared Alexis KaushanskyiD· 1 shared Arnav Lakhdive· 1 shared Joseph D. SmithiD· 1 shared Malavika K A· 1 shared Megha Manoj MenoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

Ling WeiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genome-scale prediction of context-specific synthetic lethality beyond protein interaction networks

Pravin Baskar, Sahoo Parnika, Arnav Lakhdive, Saptarshi Bej, Sanu Shameer, Kamalakannan Vijayan

This paper introduces SLxGO, a network-independent machine learning framework for predicting context-specific synthetic lethal gene pairs, achieving superior performance and validating interactions experimentally.

bioRxiv · Aug 3, 2026 · PreprintSystems Biology

A Comparative Chemical-Genetic Screen Reveals Divergent Roles for Host ALK2 Signaling Across Intracellular Bacterial Niches

Sahoo Parnika, Malavika K A, Mullai Valli Ramamoorthy, Usha Krishna, Aishani Saha, Megha Manoj Menon, Ling Wei, Sandhya Ganesan, Kamalakannan Vijayan

The paper identifies ALK2 as a critical host kinase for C. burnetii replication, while C. trachomatis suppresses ALK2 signaling, revealing divergent strategies for niche exploitation.

bioRxiv · Jul 31, 2026 · PreprintMicrobiology

Interrogating endothelial barrier regulation by temporally resolved kinase network generation

Ling Wei, Selasi Dankwa, Kamalakannan Vijayan, Joseph D. Smith, Alexis Kaushansky

This paper introduces TREKING, a method combining kinase inhibitor screens and machine learning to generate time-resolved phosphosignaling networks, revealing MAPK pathway dynamics in endothelial barrier regulation.

Life Science Alliance · Mar 11, 2024Peer-reviewedSystems Biology