The transmembrane protein TMEM127 regulates activation and fate of an MHC-I degradation complex by WWP2 modifications
Hector Gonzalez‐Cantu, Viviane Nascimento Da Conceicao, S. Yusra Munawar, Karen S Johns, Carine Jaafar, Nadia Reyna, Arshjot Multani, Cynthia María Estrada-Zúñiga, Daohong Zhou, Ricardo C.T. Aguiar, Yaxia Yuan, Patricia L. M. Dahia
This study identifies TMEM127 as a critical regulator of the MHC-I degradation complex by modulating WWP2 activity, offering a target for enhancing antigen presentation in cancer immunology.
bioRxiv · Jul 1, 2026 · PreprintMolecular Biology