Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software
Clémentine Decamps, Florian Privé, Raphael Bacher, Daniel Jost, Arthur Waguet, Eugene Andres Houseman, Eugene Lurie, Pavlo Lutsik, Aleksandar Milosavljevic, Michael Scherer, Michaël G. B. Blum, Magali Richard
This study evaluates DNA methylation deconvolution methods for cell-type proportion inference, identifies critical steps for accuracy, and develops a benchmark pipeline.
BMC Bioinformatics · Jan 13, 2020Peer-reviewedBioinformatics