Dynamic regions allosterically connect the USP14 active site with the proteasome interaction surface
Johannes Salomonsson, Linda Sjöstrand, Arvid Eskilson, Dean J. Derbyshire, Pádraig D’Arcy, Maria Sunnerhagen, Alexandra Ahlner
This study identifies dynamic loop regions in USP14 that mediate allosteric connections between the active site, Ub binding, and proteasome interaction surfaces, revealing pre-existing networks crucial for function.
Protein Science · Mar 17, 2025Peer-reviewedBiophysics