Uhrf1 loss disrupts Ctcf-associated chromatin organization during early mouse embryogenesis
Agata Kurowski, Bohan Zhu, Yifei Sun, Paul R. Sargunas, Nimisha Jain, Ashley Chan, Lahouaria Hadri, Yi Shi, Martin J. Walsh, Sai Ma
This study shows that Uhrf1 loss causes DNA methylation loss and chromatin disruption in mouse embryos, leading to developmental failure and altered lineage specification.
bioRxiv · Jul 20, 2026 · PreprintGenomics