This study shows that Uhrf1 loss causes DNA methylation loss and chromatin disruption in mouse embryos, leading to developmental failure and altered lineage specification.

bioRxiv · Jul 20, 2026 · PreprintGenomics

Early microglial priming in Alzheimer's disease revealed by ME-seq

Bohan Zhu, Anurupa Ghosh, Zhe Wang, Zhicong Liao, Michael Gyasi Appiah, Jiayi Li, Mimi Zhang, Federico Di Tullio, Agata Kurowski, John F. Fullard, Elvin Wagenblast, Martin J. Walsh, Alison Goate, Panos Roussos, Ka Lung Cheung, , Sai Ma

The paper introduces ME-seq, a technology that profiles DNA methylation, gene expression, and chromatin accessibility in single nuclei, revealing early microglial priming in Alzheimer's disease.

bioRxiv · Feb 2, 2026 · PreprintGenomics

insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology

Stanley E. Strawbridge, Agata Kurowski, Elena Corujo-Simón, Alastair Fletcher, Jennifer Nichols, Alexander George Fletcher

The paper introduces insideOutside, a method to classify interior and exterior cells in embryos using spatial data, showing improved accuracy over existing methods.

Biology Open · Aug 25, 2023Peer-reviewedDevelopmental Biology

Oct4 regulates embryonic pluripotency via metabolic mechanisms and Stat3 signalling.

Giuliano Giuseppe Stirparo, Agata Kurowski, Ayaka Yanagida, Lawrence E. Bates, Stanley E. Strawbridge, Siarhei Hladkou, Hannah T. Stuart, Thorsten Boroviak, José Silva, Jennifer Nichols

This study identifies OCT4's role in maintaining pluripotency through metabolic regulation and Stat3 signaling in mouse embryos.

Proceedings of the National Academy of Sciences · Jan 15, 2021Peer-reviewedDevelopmental Biology