Population-scale immunoglobulin genetics resolves the human B-cell system
Zain Ali, Aitzkoa Lopez de Lapuente Portilla, Guðmar Þorleifsson, Antton Lamarca Arrizabalaga, Caterina Cafaro, Gisli Hreinn Halldorsson, Ludvig Ekdahl, Mineto Ota, Páll Melsted, Lilja Stefánsdóttir, Aslaug Jonsdottir, Asgeir Sigurdsson, Erna V. Ivarsdottir, Keishi Fujio, Stephen J. Harding, , Björn Nilsson
The paper uses population-scale Ig genetics to identify genetic associations and map their effects on the human B-cell system, revealing new genes and regulatory mechanisms in humoral immunity.
bioRxiv · Apr 1, 2026 · PreprintGenomics