Aquaporin-4 and Caveolin-1 as Mediators of Fibrinogen-Driven Cerebrovascular Pathology in Cerebral Amyloid Angiopathy
Vishal Singh, Nicholas Rochakim, Francesca Ferraresso, Khushi Garg, Asma Rizvi, Arnab Choudhury, Christian J. Kastrup, Hyung Jin Ahn
This study investigates how fibrinogen contributes to CAA pathology by interacting with Aβ and affecting AQP4 and caveolin-1, showing that fibrinogen depletion reduces CAA severity and improves cognitive function.
Alzheimer s & Dementia · Jan 1, 2026Peer-reviewedNeuroscience