TREK1 upregulation is an endogenous mechanism delaying cognitive decline in Alzheimer's Disease
Tuhina Mitra, Ranjit Bhoi, Triparna Chakraborty, Asmit Moharana, Vaishnav Manoj, Hiral Rawal, Swagata Ghatak
This study identifies TREK1 upregulation as a compensatory mechanism that delays cognitive decline in Alzheimer's Disease by counteracting Aβ42o-induced neuronal hyperexcitability.
bioRxiv · Oct 16, 2025 · PreprintNeuroscience