The selective 5-HT2A receptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents
Anders A. Jensen, Cláudia R. Cecchi, Meghan Hibicke, Astrid H. Bach, Erik Kaadt, Emil Märcher-Rørsted, Charles David Nichols, Betina Elfving, Jesper Langgaard Kristensen
This paper shows that LPH-5, a selective 5-HT2A receptor agonist, produces antidepressant-like effects in rodent models, suggesting its potential as a new psychedelic-derived antidepressant.
bioRxiv · Apr 19, 2024 · PreprintNeuroscience