Concomitant DNA hydroxymethylation and histone H2B O-GlcNAcylation are prerequisites for zygotic genome activation in mice
Toshinobu Nakamura, Asuka Furuta, Tsunetoshi Nakatani, Toru Nakano
The paper identifies that DNA hydroxymethylation and histone H2B O-GlcNAcylation are both required for zygotic genome activation in mouse zygotes.
bioRxiv · Apr 27, 2026 · PreprintDevelopmental Biology