Quantitative Framework for Assessing Mesenchymal Stem Cell Quality Driven by Poised Enhancer Decommissioning
Keiko Hiraki-Kamon, Atsushi Wada, 須山 尚史, Yumi Matsuzaki, Hidemasa Kato
The paper introduces a framework to identify high-quality mesenchymal stem cells by quantifying epigenetic flaws, showing that hypermethylation of poised enhancers leads to functional decline and introducing a transcriptomic score to predict long-term proliferative potential.
bioRxiv · Apr 17, 2026 · PreprintCell Biology