Cell BiologybioRxivPreprint
Quantitative Framework for Assessing Mesenchymal Stem Cell Quality Driven by Poised Enhancer Decommissioning
Keiko Hiraki-Kamon, Atsushi Wada, 須山 尚史…·Hidemasa Kato
The paper introduces a framework to identify high-quality mesenchymal stem cells by quantifying epigenetic flaws, showing that hypermethylation of poised enhancers leads to functional decline and introducing a transcriptomic score to predict long-term proliferative potential.
DOI 10.64898/2026.04.14.718591