Dual recognition of phage SSB triggers DRT4 for antiphage defense
Monika Jasnauskaitė, Augustas Cibulskis, Kristina Kazlauskaitė, A. Skorupskaitė, J. Juozapaitis, Algirdas Mikšys, Miglė Tomkuvienė, Lina Malinauskaite, Patrick Pausch
This study identifies how DRT4, a bacterial defense system, is activated by dual recognition of phage ssDNA and the SSB protein gp44, leading to RNase activation and antiphage defense.
bioRxiv · Oct 23, 2026 · PreprintBiochemistry