Highly inducible transcription is impaired in cells lacking Cyclin T1 (CycT1) of the positive transcription factor b (P-TEFb).
Takuya Kajitani, Fang Huang, Kenji Nishiura, Dan Irwin, Aung Chein, Koh Fujinaga
This study shows that CycT1 is critical for inducible gene expression and its loss reduces JQ1-dependent gene expression, with implications for pancreatic adenocarcinoma.
bioRxiv · Sep 28, 2026 · PreprintMolecular Biology