Mdm2 restrains the activity of the CRL4Cdt2 E3 ubiquitin ligase to promote cell cycle progression through the G2/M phase
Humaira Shah, Auqib Manzoor, Tabasum Ashraf, Ashraf Dar
This study shows Mdm2 promotes cell cycle progression through degradation of Cdt2, stabilizing substrates like p21, independent of p53.
bioRxiv · Jul 9, 2025 · PreprintMolecular Biology