Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons
Sagy Krispin, Welmoed van Zuiden, Yehuda Matan Danino, Noam Rudberg, Lena Molitor, Bar Abarbanel, Gal Aviram, Gili Wolf, Chen Bar, Aviad Siani, Thea Deborah Meimoun, Alyssa N. Coyne, Marianita Santiana, Cory A. Weller, Mark Cookson, , Eran Hornstein
The paper introduces NOVA, a deep learning model for analyzing organelle structures in neurons, revealing novel ALS mechanisms through phenotypic changes in TDP-43 and P-bodies.
bioRxiv · Jan 31, 2024 · PreprintSystems Biology