Author

Welmoed van Zuiden

Weizmann Institute of ScienceORCID 0000-0001-6572-0189Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Welmoed van Zuiden1 paper · Icahn School of Medicine at Mount Sinai

Biology Disciplines

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Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Bar Abarbanel· 2 shared Eran HornsteiniD· 2 shared Nancy‐Sarah YacovzadaiD· 2 shared Thea Deborah MeimouniD· 2 shared Adam N. TrautwigiD· 1 shared Aharon NachshoniD· 1 shared Aleksandar Rajkovic· 1 shared Alyssa N. CoyneiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Bar Abarbanel

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2 papers

Recent·Most cited

TDP-43 toxic gain of function links ALS, FTD and Alzheimers Disease through splicing dysregulation

Welmoed van Zuiden, Thea Deborah Meimoun, Bar Chen, Aviad Siany, Bar Abarbanel, Lihi Moshe, Nancy‐Sarah Yacovzada, Emmanuel Amzallag, Aleksandar Rajkovic, Liat Alyagor, Eviatar Weizman, Manuela Neumann, Colin Smith, Karina McDade, Andrew Strange, , Eran Hornstein

This study identifies TDP-43-driven splicing dysregulation as a common mechanism in ALS, FTD, and Alzheimer's disease, linking them through mis-spliced mRNAs like APP.

bioRxiv · Apr 20, 2025 · PreprintNeuroscience

Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons

Sagy Krispin, Welmoed van Zuiden, Yehuda Matan Danino, Noam Rudberg, Lena Molitor, Bar Abarbanel, Gal Aviram, Gili Wolf, Chen Bar, Aviad Siani, Thea Deborah Meimoun, Alyssa N. Coyne, Marianita Santiana, Cory A. Weller, Mark Cookson, , Eran Hornstein

The paper introduces NOVA, a deep learning model for analyzing organelle structures in neurons, revealing novel ALS mechanisms through phenotypic changes in TDP-43 and P-bodies.

bioRxiv · Jan 31, 2024 · PreprintSystems Biology