A Label-Free Multi-Metric Pipeline for Benchmarking Single-Cell RNA-Sequencing Clustering and Testing the Reproducibility of Cell-Type Heterogeneity
Zachary Yousef, Jonah Simone, Dylan Klein, Heejoo Cho, Avinav Bhuyan, Priya Bhatt, Jiawei Wu, H Y Wang, Li Cai
The paper introduces a label-free pipeline to benchmark single-cell RNA-seq clustering and assesses the reproducibility of cell-type heterogeneity across different embeddings and resampling methods.
bioRxiv · Jul 20, 2026 · PreprintBioinformatics