Kinetic proofreading decouples signal strength and range in paracrine gradient formation
Purushottam D. Dixit, Aviral Jain
The paper explains how weak-affinity ligands can drive broader signaling activity than strong-affinity ligands by showing that receptor architecture decouples signal strength and range through kinetic proofreading.
bioRxiv · Jul 22, 2026 · PreprintBiophysics