Open-State Dynamics and Allosteric Modulation of the α1β3γ2 GABAA Receptor Stabilized by L9'T/S Substitutions
Ayobami Diyaolu, Cecilia M. Borghese, Marcel P Goldschen-Ohm, Senthil Natesan
This study stabilizes an open-state conformation of the α1β3γ2 GABAAR using mutations and simulations, revealing how allosteric modulators and antagonists affect receptor gating.
Journal of Chemical Information and Modeling · May 25, 2026Peer-reviewedBiophysics