Senthil Natesan

Open-State Dynamics and Allosteric Modulation of the α1β3γ2 GABAA Receptor Stabilized by L9'T/S Substitutions

This study stabilizes an open-state conformation of the α1β3γ2 GABAAR using mutations and simulations, revealing how allosteric modulators and antagonists affect receptor gating.

Structural Mechanisms Underlying Distinct Binding and Activities of 18:0 and 18:1 Lysophosphatidic acids at LPA1 Receptor

This study investigates how 18:0 and 18:1 lysophosphatidic acids bind and activate LPA1 receptor differently using molecular dynamics simulations.

Structural basis for the access and binding of resolvin D1 (RvD1) to formyl peptide receptor 2 (FPR2/ALX), a class A GPCR

This study investigates how RvD1 accesses and binds to FPR2/ALXR using molecular dynamics and metadynamics simulations, revealing structural insights and potential therapeutic implications.

Structural insights into the molecular recognition of integrin αVβ3 by RGD-containing ligands: The role of the specificity-determining loop (SDL)

This study analyzes the molecular interactions and structural changes of integrin αVβ3's ligand-binding domain to identify key residues and allosteric mechanisms involved in ligand recognition and regulation.

Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infection

This study identifies extracellular ISG15 as a soluble antiviral factor that promotes IFN-independent ISGylation through integrin-FAK pathway activation during virus infection.