Cation binding to SERCA
B. Sun, B. D. Stewart, A. N. Kucharski, P. M. Kekenes-Huskey
This study uses computational methods to analyze cation binding to SERCA, finding that Ca2+ is preferentially coordinated over Mg2+ and K+ at sites I and II, with Mg2+ acting as an inhibitor and K+ as an intermediate in the reaction cycle.
bioRxiv · Jan 1, 2019 · PreprintBiochemistry